除了小分子抑制剂,核酸技术也开始在ACH治疗中得到应用。Ribomic开发的RBM-007,通过限制FGF2和FGFR3激活变体之间的过度相互作用发挥功能。2期临床结果显示,RBM-007的疗效与Vosoritide相近(1.5厘米/年),甚至有一名受试者年增长5厘米,且该试验中包括2周一次的注射频率,是当前在研药物中最长的给药间隔。
Nature, Published online: 25 February 2026; doi:10.1038/s41586-026-10162-x
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Influencers have had a bad time of it at restaurants recently. There they are, just trying to record a quick video and take a few pictures of their lunch, and restaurateur Jeremy King (of the Ivy and the Wolseley in London) goes and writes an article saying they’re ruining the dining experience of “bona fide guests” – something he says staff are “desperately trying to stop”. I’ve read pieces calling TikTok the end of the London restaurant scene. Friends’ parents have even said they would get up and leave if they were sitting next to anyone filming their meal.
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